Medically Challenging Case Shows NSAIDs Can Prompt Exercise-Induced Anaphylaxis

40-year-old marathon runner developsanaphylaxisafter taking NSAID before her run

NEW ORLEANS (November 5, 2021)– Severe allergic reactions, known as anaphylaxis, are scary, and it can sometimes be hard to determine the cause. A new medically challenging case presented at this year’s American College of Allergy,Asthma is a chronic, inflammatory lung disease characterized by recurrent breathing problems. People with asthma have acute episodes where the air passages in their lungs get narrower, and breathing becomes more difficult. Sometimes episodes of asthma are triggered by allergens, although infection, exercise, cold air and other factors are also important triggers." rel="tooltip">Asthmaand Immunology (ACAAI) Annual Scientific Meeting reports a situation in which a non-steroidal anti-inflammatory drug (NSAID) caused an anaphylactic reaction in a female runner. NSAIDs are medicines that are widely used to relieve pain, reduceInflammation is the redness, swelling, heat and pain in a tissue due to chemical or physical injury, or to infection. It is a characteristic of allergic reactions in the nose, lungs, and skin." rel="tooltip">inflammation, and bring down a high temperature.

“We saw a 40-year-old avid runner in our clinic who had no history of food or medication allergies,” says Sebastian Sylvestre, MD, ACAAI member and lead author of the abstract. “She had previously tolerated NSAIDs, and she took naproxen before her marathon training run. By mile four she had developed itching and swelling around her eyes. By mile six she had hives, lightheadedness, difficulty breathing, and vomiting. Her husband brought her to the emergency room for treatment.”

The abstract authors note that NSAIDs are capable of both bringing on allergic responses and heightening the reaction in certain individuals.

“The combination of NSAID use and exercise may predispose some people to anaphylaxis,” says allergist Taha Al-Shaikhly, MD, ACAAI member and co-author of the paper. “It is important that those who engage in strenuous exercise be mindful of the phenomenon and they know the risks, as well as how to manage any anaphylactic symptoms that might arise in the future during exercise.”

The authors note that following the emergency room visit, the patient now strictly avoids NSAIDs, carries anEpinephrine is a naturally occurring hormone, also called adrenaline. It is one of two chemicals (the other is norepinephrine) released by the adrenal gland. Epinephrine increases the speed and force of heart beats and thereby the work that can be done by the heart. It dilates the airways to improve breathing and narrows blood vessels in the skin and intestine so that an increased flow of blood reaches the muscles and allows them to cope with the demands of exercise. Epinephrine has been produced synthetically as a drug since 1900. It remains the drug of choice for treatment of anaphylaxis." rel="tooltip">epinephrine汽车喷油器治疗速发型过敏反应,也没有哈d a recurrence of symptoms with exercise. Just because an allergic person has never had an anaphylactic reaction in the past to an offending allergen, doesn’t mean one won’t occur in the future. And if you have had an anaphylactic reaction in the past, you are at risk of future reactions.

Abstract Title: NSAID Associated Exercise-Induced Anaphylaxis
Presenter: Sebastian Sylvestre, MD

For more information about allergies and asthma, or to find an allergist in your area, visitAllergyandAsthmaRelief.org. The ACAAI Virtual Annual Meeting is Nov. 4-8. For more news and research from the ACAAI Scientific Meeting, go to ourNews page– and follow the conversation on Twitter#ACAAI21.

About ACAAI
The ACAAI is a professional medical organization of more than 6,000 allergists-immunologists and allied health professionals, headquartered in Arlington Heights, Ill. The College fosters a culture of collaboration and congeniality in which its members work together and with others toward the common goals of patient care, education, advocacy, and research. ACAAI allergists are board-certified physicians trained to diagnose allergies and asthma, administerImmunotherapy is a form of preventive and anti-inflammatory treatment of allergy to substances such as pollens, house dust mites, fungi, and stinging insect venom. Immunotherapy involves giving gradually increasing doses of the substance, or allergen, to which the person is allergic. The incremental increases of the allergen cause the immune system to become less sensitive to the substance, perhaps by causing production of a particular "blocking" antibody, which reduces the symptoms of allergy when the substance is encountered in the future." rel="tooltip">immunotherapy, and provide patients with the best treatment outcomes. For more information and to find relief, visitAllergyandAsthmaRelief.org. Join us onFacebook,PinterestandTwitter.